Title : Regulation of PGE2 signaling pathways and TNF-alpha signaling pathways on the function of bone marrow-derived dendritic cells and the effects of CP-25.

Pub. Date : 2015 Dec 15

PMID : 26415983






2 Functional Relationships(s)
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1 PGE2 increased the expressions of EP4, NF-kappaB and down-regulated cAMP level of DCs. Dinoprostone nuclear factor kappa B subunit 1 Homo sapiens
2 These results demonstrate that PGE2 and TNF-alpha could enhance DCs functions by mediating PGE2-EP4-cAMP pathway, TNF-alpha-TNFR1-TRADD-TRAF2-NF-kappaB pathway respectively. Dinoprostone nuclear factor kappa B subunit 1 Homo sapiens