Pub. Date : 2015
PMID : 26412948
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2 Elevates IL-23 Production in Human Dendritic Cells via a cAMP Dependent Pathway. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 2 | Whether this differential effect of PGE2 on IL-23 production is cell-type- or species-specific has not been investigated in detail. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 3 | The present study was designed to investigate the effect of PGE2 on IL-23 production in human DCs and the possible underlying mechanisms. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 4 | Our results demonstrated that PGE2 promoted zymosan-induced IL-23 production in a concentration dependent manner. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 5 | In addition, it was found that PGE2 is also able to elevate MyD88-mediated IL-23 p19 promoter activity. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 6 | More importantly, ELISA data demonstrated that db-cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, can mimic the effect of PGE2 on zymosan-induced IL-23 production, and rp-cAMP, a protein kinase A (PKA) inhibitor, can block the effect of PGE2. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 7 | More importantly, ELISA data demonstrated that db-cAMP, a cAMP analog, and forskolin, an adenylate cyclase activator, can mimic the effect of PGE2 on zymosan-induced IL-23 production, and rp-cAMP, a protein kinase A (PKA) inhibitor, can block the effect of PGE2. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 8 | Moreover, PGE2 can increase zymosan-induced expression of the mRNA levels of both p19 and p40 subunits, which was mimicked by db-cAMP and forskolin. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |
| 9 | Our data suggest that PGE2 elevates the production of IL-23 in human Mo-DCs via a cAMP dependent pathway. | Dinoprostone | interleukin 23 subunit alpha | Homo sapiens |