Title : A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?

Pub. Date : 2015 Aug 26

PMID : 26405692






1 Functional Relationships(s)
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1 The G-quadruplex (G4) sequences regulating the c-MYC, KRAS, VEGF, BCL-2, HIF-1alpha, and RET oncogenes, as examples, are targets for oxidation at loop and 5"-core guanines (G) as showcased in this study by CO3 - oxidation of the VEGF G4. Guanine ret proto-oncogene Homo sapiens