Pub. Date : 2016 Sep
PMID : 26404762
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 2 | The present study demonstrated that arsenic exposure resulted in protein and enzymatic induction of heme oxygenase-1 (HO-1) in dose- and time-dependent manners in HK-2 cells. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 3 | The present study demonstrated that arsenic exposure resulted in protein and enzymatic induction of heme oxygenase-1 (HO-1) in dose- and time-dependent manners in HK-2 cells. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 4 | Blocking HO-1 enzymatic activity by zinc protoporphyrin (ZnPP) augmented arsenic-induced apoptosis, ROS production and mitochondrial dysfunction, suggesting a critical role for HO-1 as a renal protectant in this procession. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 5 | Blocking HO-1 enzymatic activity by zinc protoporphyrin (ZnPP) augmented arsenic-induced apoptosis, ROS production and mitochondrial dysfunction, suggesting a critical role for HO-1 as a renal protectant in this procession. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 6 | On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 7 | Our results revealed that the regulation of arsenic-induced HO-1 expression was performed through multiple ROS-dependent signal pathways and the corresponding transcription factors, including p38 MAPK and JNK (but not ERK), AP-1, Nrf2 and NF-kappaB. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 8 | TMP inhibited arsenic-induced activations of JNK, p38 MAPK, ERK, AP-1 and Nrf2 and block HO-1 protein expression. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 9 | In summary, our study highlighted a role of HO-1 in the protection against arsenic-induced cytotoxicity downstream from the primary targets of TMP and further indicated that TMP may be used as a potential therapeutic agent in the treatment of arsenic-induced nephrotoxicity. | Arsenic | heme oxygenase 1 | Homo sapiens |
| 10 | In summary, our study highlighted a role of HO-1 in the protection against arsenic-induced cytotoxicity downstream from the primary targets of TMP and further indicated that TMP may be used as a potential therapeutic agent in the treatment of arsenic-induced nephrotoxicity. | Arsenic | heme oxygenase 1 | Homo sapiens |