Title : Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells.

Pub. Date : 2016 Jan

PMID : 26403645






1 Functional Relationships(s)
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1 Upon exposure to ferroptosis-inducing compounds (e.g., erastin, sorafenib, and buthionine sulfoximine), p62 expression prevented NRF2 degradation and enhanced subsequent NRF2 nuclear accumulation through inactivation of Kelch-like ECH-associated protein 1. Sorafenib kelch like ECH associated protein 1 Homo sapiens