Title : A Critical Proton MR Spectroscopy Marker of Alzheimer's Disease Early Neurodegenerative Change: Low Hippocampal NAA/Cr Ratio Impacts APOE ɛ4 Mexico City Children and Their Parents.

Pub. Date : 2015

PMID : 26402110






3 Functional Relationships(s)
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1 A Critical Proton MR Spectroscopy Marker of Alzheimer"s Disease Early Neurodegenerative Change: Low Hippocampal NAA/Cr Ratio Impacts APOE e4 Mexico City Children and Their Parents. 1-naphthaleneacetic acid apolipoprotein E Homo sapiens
2 The NAA/Cr ratio in right hippocampus in controls versus APOE e4 MC children and in left hippocampus in MC APOE e4 parents versus their children was significantly different after adjusting for age, gender, and BMI (p = 0.027 and 0.01, respectively). 1-naphthaleneacetic acid apolipoprotein E Homo sapiens
3 Decreases in NAA/Cr correlate well with cognitive function, behavioral symptoms, and dementia severity; thus, since the progression of AD starts decades before clinical diagnosis, our findings support the hypothesis that under chronic exposures to fine particulate matter and ozone above the standards, neurodegenerative processes start in childhood and APOE e4 carriers are at higher risk. 1-naphthaleneacetic acid apolipoprotein E Homo sapiens