Title : Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord.

Pub. Date : 2015 Sep 23

PMID : 26394827






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1 RESULTS: Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin 6) and nuclear factor-kappa B activity. Morphine tumor necrosis factor Rattus norvegicus