Title : Functional requirement of tyrosine residue 429 within CD5 cytoplasmic domain for regulation of T cell activation and survival.

Pub. Date : 2015 Oct 23

PMID : 26363459






1 Functional Relationships(s)
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1 TCR crosslinking leads to phosphorylation of three tyrosine residues within the cytoplasmic tail of CD5 (Y429, Y441 and Y463) leading to the recruitment of signaling molecules like PI3K, c-Cbl and RasGAP; nevertheless, the role of these residues in T cell survival has not yet been assessed. Tyrosine Cbl proto-oncogene Homo sapiens