Title : Rosiglitazone activation of PPARĪ³-dependent signaling is neuroprotective in mutant huntingtin expressing cells.

Pub. Date : 2015 Nov 1

PMID : 26362846






2 Functional Relationships(s)
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1 Using a mouse model of Huntington"s Disease (HD), we recently showed that PPARgamma not only played a major function in preventing HD, but also oral intake of a PPARgamma agonist (thiazolidinedione, TZD) significantly reduced the formation of mutant Huntingtin (mHtt) aggregates in the brain (e.g., cortex and striatum). tzd peroxisome proliferator activated receptor gamma Mus musculus
2 Using a mouse model of Huntington"s Disease (HD), we recently showed that PPARgamma not only played a major function in preventing HD, but also oral intake of a PPARgamma agonist (thiazolidinedione, TZD) significantly reduced the formation of mutant Huntingtin (mHtt) aggregates in the brain (e.g., cortex and striatum). tzd peroxisome proliferator activated receptor gamma Mus musculus