Title : Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

Pub. Date : 2015 Dec

PMID : 26361725






1 Functional Relationships(s)
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1 We aimed to clarify the roles of the multidrug transporters ABCB1 and ABCG2 in oral availability and brain accumulation of ceritinib, an oral anaplastic lymphoma kinase (ALK) inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) after progression on crizotinib. Crizotinib ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus