Title : The effect of glucuronidation on isoflavone induced estrogen receptor (ER)α and ERβ mediated coregulator interactions.

Pub. Date : 2015 Nov

PMID : 26361015






3 Functional Relationships(s)
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1 Glucuronidation changed the preferential activation of genistein from ERbeta-LBD to ERalpha-LBD and further increased the slightly preferential activation of daidzein for ERalpha-LBD. daidzein estrogen receptor 1 Homo sapiens
2 Our results show that genistein and daidzein remain agonistic ligands of ERalpha-LBD and ERbeta-LBD in their conjugated form with a higher relative preference for ERalpha-LBD than the corresponding aglycones. daidzein estrogen receptor 1 Homo sapiens
3 Our results show that genistein and daidzein remain agonistic ligands of ERalpha-LBD and ERbeta-LBD in their conjugated form with a higher relative preference for ERalpha-LBD than the corresponding aglycones. daidzein estrogen receptor 1 Homo sapiens