Title : Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells.

Pub. Date : 2015 Oct 6

PMID : 26353932






1 Functional Relationships(s)
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1 Systematic analysis of drug uptake, DNA adduct formation and DNA damage responses implicated in cisplatin adducts removal revealed that the KRAS(G12C) mutation might be particular because it stimulates Base Excision Repair to rapidly remove platinum from DNA even before the formation of cross-links. Platinum KRAS proto-oncogene, GTPase Homo sapiens