Pub. Date : 2015
PMID : 26352431
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HIF1alpha-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | We have shown recently that LPA increases hypoxia-inducible factor 1alpha (HIF1alpha) expression. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | We found that MIF regulation by LPA was ablated by knockdown of HIF1alpha, indicating that MIF is a transcriptional target of HIF1alpha. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | We found that MIF regulation by LPA was ablated by knockdown of HIF1alpha, indicating that MIF is a transcriptional target of HIF1alpha. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | Conversely, knockdown of MIF ablated an increase in HIF1alpha expression in LPA-treated cells, suggesting a reciprocal relationship between HIF1alpha and MIF. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 6 | Conversely, knockdown of MIF ablated an increase in HIF1alpha expression in LPA-treated cells, suggesting a reciprocal relationship between HIF1alpha and MIF. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 7 | LPA stimulated co-immunoprecipitation of HIF1alpha and MIF, indicating that their association is necessary for stabilization of HIF1alpha. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 8 | LPA stimulated co-immunoprecipitation of HIF1alpha and MIF, indicating that their association is necessary for stabilization of HIF1alpha. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 9 | We found that LPA did not alter expression of CSN5, but stimulated its interaction with HIF1alpha and MIF. | lysophosphatidic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |