Title : Benzimidazole Derivatives as Potent JAK1-Selective Inhibitors.

Pub. Date : 2015 Sep 24

PMID : 26351728






1 Functional Relationships(s)
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1 One of the synthesized compounds, 1-(2-aminoethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxamide (5c), showed remarkable JAK1 selectivity (63-fold vs JAK2, 25-fold vs JAK3, and 74-fold vs Tyk2). 1-(2-aminoethyl)-2-(piperidin-4-yl)-1H-benzo(d)imidazole-5-carboxamide Janus kinase 1 Homo sapiens