Title : Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors.

Pub. Date : 2015 Oct

PMID : 26351135






1 Functional Relationships(s)
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1 RESULTS: The two Pim1 inhibitors increased the potency of flavopiridol, mitoxantrone, topotecan and doxorubicin, specifically in ABCG2-expressing cells. Mitoxantrone Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens