Title : Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.

Pub. Date : 2015 Sep 14

PMID : 26343583






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Due to these unique properties, LY3009120 demonstrates minimal paradoxical activation, inhibits MEK1/2 phosphorylation, and exhibits anti-tumor activities across multiple models carrying KRAS, NRAS, or BRAF mutation. LY3009120 NRAS proto-oncogene, GTPase Homo sapiens