Title : Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.

Pub. Date : 2015 Sep 14

PMID : 26343583






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 LY3009120 induces BRAF-CRAF dimerization but inhibits the phosphorylation of downstream MEK and ERK, suggesting that it effectively inhibits the kinase activity of BRAF-CRAF heterodimers. LY3009120 mitogen-activated protein kinase kinase 7 Homo sapiens