Pub. Date : 2015 Dec
PMID : 26341143
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GTP-dependent interaction between phospholipase D and dynamin modulates fibronectin-induced cell spreading. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 2 | Dynamin as a PLD-interacting partner is a large GTP binding protein that has been considered a mechanochemical enzyme involved in endocytosis by hydrolyzing GTP. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 3 | Dynamin as a PLD-interacting partner is a large GTP binding protein that has been considered a mechanochemical enzyme involved in endocytosis by hydrolyzing GTP. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 4 | Here, we demonstrate that PLD can be regulated by dynamin in a GTP-dependent manner and that this is critical for FN-mediated cell spreading. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 5 | Moreover, PLD interacted with dynamin in a GTP-dependent manner in FN signaling, and this interaction was crucial for FN-induced PLD activation and cell spreading. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 6 | Moreover, PLD interacted with dynamin in a GTP-dependent manner in FN signaling, and this interaction was crucial for FN-induced PLD activation and cell spreading. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 7 | Also, we found that PLD mutant (R128K) that didn"t have GAP activity increased the GTP-dependent interaction between PLD and dynamin; it also increased PLD activity and cell spreading. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 8 | Also, we found that PLD mutant (R128K) that didn"t have GAP activity increased the GTP-dependent interaction between PLD and dynamin; it also increased PLD activity and cell spreading. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 9 | Also, we found that PLD mutant (R128K) that didn"t have GAP activity increased the GTP-dependent interaction between PLD and dynamin; it also increased PLD activity and cell spreading. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 10 | These results imply that GTP-loaded dynamin, like a small GTPase could mediate a "switch on" signaling via interaction with PLD that has a role as an effector. | Guanosine Triphosphate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |