Title : Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats.

Pub. Date : 2016 Sep

PMID : 26328539






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1 Together, these results suggest that long-term dietary intake of ALA enhances CREB/BDNF/TrkB pathway through the activation of ERK and Akt signalings in hippocampus, which contributes to its ameliorative effects on cognitive deficits in natural aging. alpha-Linolenic Acid AKT serine/threonine kinase 1 Rattus norvegicus