Title : Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients.

Pub. Date : 2016 Jan

PMID : 26317320






2 Functional Relationships(s)
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1 Simulations indicated concomitant strong CYP3A4 inhibitors or inducers had relevant effects on naloxegol exposure. naloxegol cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CONCLUSIONS: Administration of strong CYP3A4 inhibitors or inducers had a clinically relevant influence on naloxegol pharmacokinetics. naloxegol cytochrome P450 family 3 subfamily A member 4 Homo sapiens