Pub. Date : 2015
PMID : 26315049
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This phenotypic change in CD38-/- CAMs was enhanced by 7-ketocholesterol (7-Ket), an atherogenic stimulus. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 2 | This phenotypic change in CD38-/- CAMs was enhanced by 7-ketocholesterol (7-Ket), an atherogenic stimulus. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 3 | In contrast, the overexpression of Nrf2 gene abolished 7-Ket-induced dedifferentiation in CD38-/- CAMs. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 4 | It was demonstrated that in CD38-/- CAMs, 7-Ket failed to stimulate the production of O2-., while in CD38+/+ CAMs 7-Ket induced marked O2-. | 7-ketocholesterol | CD38 antigen | Mus musculus |
| 5 | CONCLUSION: Taken together, these results suggest that CD38 activity is required for 7-Ket-induced Ca2+ and consequently O2-. | 7-ketocholesterol | CD38 antigen | Mus musculus |