Pub. Date : 2015 Aug 27
PMID : 26313911
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | alpha-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway. | alpha-solanine | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Moreover, we found downregulation of phosphorylated Akt (Thr308 and Ser473), mammalian target of rapamycin (mTOR; Ser2448 and Ser2481) and 4E-BP1 (Thr37/46) by alpha-solanine implying suppression of the Akt/mTOR pathway. | alpha-solanine | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Collectively, our results signify that alpha-solanine induces autophagy to exert anti-proliferative activity by triggering ER stress and inhibiting Akt/mTOR signaling pathway. | alpha-solanine | mechanistic target of rapamycin kinase | Homo sapiens |