Pub. Date : 2015 Oct 6
PMID : 26311740
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway. | Sorafenib | microRNA 21 | Homo sapiens |
| 2 | Differential screening of miRNAs showed higher levels of miR-21 in sorafenib-resistant HCC cells. | Sorafenib | microRNA 21 | Homo sapiens |
| 3 | Exposure of HCC cells to sorafenib led to an increase in miR-21 expression, a decrease in PTEN expression and sequential Akt activation. | Sorafenib | microRNA 21 | Homo sapiens |
| 4 | Transfection of miR-21 mimics in HCC cells restored sorafenib resistance by inhibiting autophagy. | Sorafenib | microRNA 21 | Homo sapiens |
| 5 | Anti-miR-21 oligonucleotides re-sensitized sorafenib-resistant cells by promoting autophagy. | Sorafenib | microRNA 21 | Homo sapiens |
| 6 | Inhibition of miR-21 enhances the efficacy of sorafenib in treating sorafenib-resistant HCC tumors in vivo. | Sorafenib | microRNA 21 | Homo sapiens |
| 7 | Inhibition of miR-21 enhances the efficacy of sorafenib in treating sorafenib-resistant HCC tumors in vivo. | Sorafenib | microRNA 21 | Homo sapiens |
| 8 | We conclude that miR-21 participates in the acquired resistance of sorafenib by suppresing autophagy through the Akt/PTEN pathway. | Sorafenib | microRNA 21 | Homo sapiens |
| 9 | MiR-21 could serve as a therapeutic target for overcoming sorafenib resistance in the treatment of HCC. | Sorafenib | microRNA 21 | Homo sapiens |