Title : Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer.

Pub. Date : 2015 Nov 1

PMID : 26310874






1 Functional Relationships(s)
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1 Further, resveratrol significantly attenuated drug resistance through inhibition of epithelial-mesenchymal transition (EMT) factors (decreased vimentin and slug, increased E-cadherin) and down-regulation of NF-kappaB activation and its translocation to the nucleus and abolished NF-kappaB-regulated gene end-products (MMP-9, caspase-3). Resveratrol matrix metallopeptidase 9 Homo sapiens