Title : Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides.

Pub. Date : 2015 Sep 21

PMID : 26304691






1 Functional Relationships(s)
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1 While N-acetyl-p-benzoquinoneimine (NAPQI), an electrophilic metabolite of acetaminophen (APAP), has been found to undergo GSH conjugation associated with its detoxification, interaction of NAPQI with nucleophilic per- and polysulfides produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase, and/or other enzymes is not known. 4-amino-N-acetyl-N-methylaniline cystathionine beta-synthase Mus musculus