Pub. Date : 2015 Oct 15
PMID : 26302449
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin ameliorates lipotoxicity-induced mesangial cell apoptosis partly via upregulation of glucagon like peptide-1 receptor (GLP-1R). | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 2 | Metformin ameliorates lipotoxicity-induced mesangial cell apoptosis partly via upregulation of glucagon like peptide-1 receptor (GLP-1R). | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 3 | Interestingly, metformin, one of the biguanide drugs that has anti-diabetic effects, attenuated lipotoxicity-induced mesangial cell apoptosis and restored GLP-1R expression. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 4 | Furthermore, we provided the evidence that metformin treatment has a renal protective effect partly via increased mesangial GLP-1R expression. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 5 | Our data suggested that regulation of GLP-1R expression could be a promising approach to treat diabetic nephropathy and the novel mechanism of metformin mediated GLP-1R regulation. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |
| 6 | Our data suggested that regulation of GLP-1R expression could be a promising approach to treat diabetic nephropathy and the novel mechanism of metformin mediated GLP-1R regulation. | Metformin | glucagon-like peptide 1 receptor | Mus musculus |