Title : Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.

Pub. Date : 2015 Dec 15

PMID : 26296355






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Lapatinib alone acutely inhibited all HER receptors and effectors but led to delayed rephosphorylation of HER3 and EGFR and partial restoration of ERK and AKT activity. Lapatinib mitogen-activated protein kinase 1 Homo sapiens
2 When combined with lapatinib, trastuzumab prevented HER3/EGFR reactivation and caused prolonged inhibition of ERK/AKT. Lapatinib mitogen-activated protein kinase 1 Homo sapiens