Title : Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions.

Pub. Date : 2016 Feb

PMID : 26296158






4 Functional Relationships(s)
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1 Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions. glyceollin ATP binding cassette subfamily C member 2 Homo sapiens
2 Specifically, studies were undertaken in Caco-2 cells to evaluate glyceollins" effects on apical efflux transporters, namely, MRP2 and BCRP, which are the locus of several intestinal drug-drug and drug-food interactions. glyceollin ATP binding cassette subfamily C member 2 Homo sapiens
3 Glyceollins were shown to reverse MRP2-mediated CDF transport asymmetry in a concentration-dependent manner, with activity similar to the MRP2 inhibitor, MK-571. glyceollin ATP binding cassette subfamily C member 2 Homo sapiens
4 Glyceollins were shown to reverse MRP2-mediated CDF transport asymmetry in a concentration-dependent manner, with activity similar to the MRP2 inhibitor, MK-571. glyceollin ATP binding cassette subfamily C member 2 Homo sapiens