Pub. Date : 2015 Oct 15
PMID : 26294671
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 2 | Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 3 | Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 4 | Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 5 | Divalent metal-ion transporter-1 (DMT1) is a widely expressed iron-preferring membrane-transport protein that serves a critical role in erythroid iron utilization. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 6 | That the anemia was due to iron deficiency was demonstrated by the following observations in DMT1(int/int) mice: 1) blood iron and tissue nonheme-iron stores were depleted; 2) mRNA expression of liver hepcidin (Hamp1) was depressed; and 3) intraperitoneal iron injection corrected the anemia, and reversed the changes in blood iron, nonheme-iron stores, and hepcidin expression levels. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 7 | We observed decreased total iron content in multiple tissues from DMT1(int/int) mice compared with DMT1(+/+) mice but no meaningful change in copper, manganese, or zinc. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 8 | DMT1(int/int) mice absorbed (64)Cu and (54)Mn from an intragastric dose to the same extent as did DMT1(+/+) mice but the absorption of (59)Fe was virtually abolished in DMT1(int/int) mice. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 9 | This study reveals a critical function for DMT1 in intestinal nonheme-iron absorption for normal growth and development. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |