Title : Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts.

Pub. Date : 2015 Dec 15

PMID : 26289070






1 Functional Relationships(s)
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1 In contrast, PDX tumors harboring mutated PIK3CA demonstrated partial resistance to ASLAN002, which was overcome with addition of NVP-BKM120 to the treatment regimen. NVP-BKM120 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens