Pub. Date : 2015
PMID : 26284193
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The key regulator of UPR-mediated apoptosis, CHOP/GADD153 and endoplasmic reticulum resident chaperone BiP/GRP78 were parallely up-regulated with activation of two major sensors of the UPR [PERK and ATF-6 in PA-1; PERK, and IRE1alpha in SKOV-3) in response to ROS accumulation induced by PEITC (5 muM). | Reactive Oxygen Species | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |
| 2 | ROS scavenger, N-acetyl-L-cysteine (NAC), attenuated the effect of PEITC on UPR signatures (P-PERK, IRE1alpha, CHOP/GADD153, and BiP/GRP78), suggesting the involvement of ROS in UPR-mediated apoptosis. | Reactive Oxygen Species | endoplasmic reticulum to nucleus signaling 1 | Homo sapiens |