Pub. Date : 2015 Nov 16
PMID : 26275776
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here, we show that, in response to replication perturbation induced by low doses of the TOP1 inhibitor camptothecin, loss of the WRN exonuclease resulted in enhanced degradation and ssDNA formation at nascent strands by the combined action of MRE11 and EXO1, as opposed to the limited processing of nascent strands performed by DNA2 in wild-type cells. | Camptothecin | WRN RecQ like helicase | Homo sapiens |