Title : The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.

Pub. Date : 2015 Nov 16

PMID : 26275776






1 Functional Relationships(s)
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1 Here, we show that, in response to replication perturbation induced by low doses of the TOP1 inhibitor camptothecin, loss of the WRN exonuclease resulted in enhanced degradation and ssDNA formation at nascent strands by the combined action of MRE11 and EXO1, as opposed to the limited processing of nascent strands performed by DNA2 in wild-type cells. Camptothecin WRN RecQ like helicase Homo sapiens