Title : Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.

Pub. Date : 2015 Dec

PMID : 26271487






1 Functional Relationships(s)
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1 UNLABELLED: The bioactive sphingolipid sphingosine-1-phosphate (S1P) drives several hallmark processes of cancer, making the enzymes that synthesize S1P, that is, sphingosine kinase 1 and 2 (SK1 and SK2), important molecular targets for cancer drug development. Sphingolipids sphingosine kinase 2 Homo sapiens