Protein Name sphingosine kinase 2
Organism Homo sapiens
Gene ID 56848
Gene Symbol

SPHK2

UniProt Q9NRA0 (SPHK2_HUMAN), A0A024QZH5 (A0A024QZH5_HUMAN), E9PCV4 (E9PCV4_HUMAN), B3KV83 (B3KV83_HUMAN)
Relationships Total Number of functionally related compound(s) : 153
Total Number of Articles : 197
Description

sphingosine kinase 2

Gene Summary

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

synonyms
  • sphingosine kinase 2
  • SK 2
  • SK-2
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Properties