Title : AMPK dependent protective effects of metformin on tumor necrosis factor-induced apoptotic liver injury.

Pub. Date : 2015 Sep 25

PMID : 26265045






3 Functional Relationships(s)
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1 In the present study, the potential modulatory effects of metformin on TNF-alpha-dependent apoptotic liver damage was investigated in mice with TNF-alpha/d-galactosamine (D-Gal)-induced liver injury. Metformin tumor necrosis factor Mus musculus
2 In the present study, the potential modulatory effects of metformin on TNF-alpha-dependent apoptotic liver damage was investigated in mice with TNF-alpha/d-galactosamine (D-Gal)-induced liver injury. Metformin tumor necrosis factor Mus musculus
3 These data indicated that metformin effectively alleviated TNF-alpha/D-Gal-induced apoptotic liver injury and these beneficial effects were at least partially mediated by AMPK. Metformin tumor necrosis factor Mus musculus