Pub. Date : 2015
PMID : 26261481
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin inhibits cell proliferation and promotes apoptosis in human osteoclastoma cell through MMP-9, NF-kappaB and JNK signaling pathways. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Firstly, MMP-9, NF-kappaB and JNK inhibitors were added into GCT cells and which was researched the mechanism of curcumin on human GCT cells. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Furthermore, curcumin inhibited the MMP-9 gene expression quantity and NF-kappaB activity, and activated JNK protein expression in GCT cells. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Interesting, down-regulation of JNK protein expression could also reversed the anti-cancer effect of curcumin on cell viability of GCT cells. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Taken together, our results suggest that curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-kappaB, and activation JNK signaling pathways. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |