Title : Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release.

Pub. Date : 2015 Nov

PMID : 26259827






1 Functional Relationships(s)
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1 The role of endogenous 5-HT in enhancing the effect of amphetamine was confirmed showing that treatment with the 5-HT precursor 5-hydroxytryptophan (10 mg/kg) restored tissue and extracellular levels of brain 5-HT and the effects of amphetamine on striatal NA release and motor activity in Tph2(-/-) mice. 5-Hydroxytryptophan tryptophan hydroxylase 2 Mus musculus