Protein Name tryptophan hydroxylase 2
Organism Mus musculus
Gene ID 216343
Gene Symbol

Tph2

UniProt Q8CGV2 (TPH2_MOUSE)
Relationships Total Number of functionally related compound(s) : 56
Total Number of Articles : 129
Description

tryptophan hydroxylase 2

Gene Summary

Enables tryptophan 5-monooxygenase activity. Predicted to be involved in aromatic amino acid family metabolic process. Predicted to act upstream of or within serotonin biosynthetic process from tryptophan. Located in neuron projection. Is expressed in early conceptus; germ cell of ovary; nervous system; retina; and tongue. Used to study endogenous depression. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • tryptophan 5-hydroxylase 2
  • neuronal tryptophan hydroxylase
  • tryptophan 5-monooxygenase 2
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Properties