Title : Acute nicotine treatment attenuates lipopolysaccharide-induced cognitive dysfunction by increasing BDNF expression and inhibiting neuroinflammation in the rat hippocampus.

Pub. Date : 2015 Sep 14

PMID : 26259694






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1 We found that acute nicotine injection markedly attenuated LPS-elicited cognitive deficits and suppressed the strong LPS-induced release of IL-1beta, IL-6, and TNF-alpha into serum and the dorsal hippocampus at 4 and 24h after LPS injection. Nicotine interleukin 6 Rattus norvegicus