Title : Purification and Structural Characterization of "Simple Catechol", the NGAL-Siderocalin Siderophore in Human Urine.

Pub. Date : 2015 Jan 1

PMID : 26257890






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 NGAL-Siderocalin binds and sequesters the iron loaded bacterial siderophore enterochelin (Ent), defining the protein as an innate immune effector. Iron lipocalin 2 Homo sapiens
2 While different catechols have been detected in human urine, they have not been directly purified from a biofluid and demonstrated to ligate iron with NGAL-Siderocalin. Iron lipocalin 2 Homo sapiens
3 This paper describes a "natural products" approach to identify small molecules that mediate iron binding to NGAL-Siderocalin. Iron lipocalin 2 Homo sapiens
4 Although catechol was a known NGAL-Siderocalin co-factor, our purification directly confirmed its presence in urine as well as its capacity to serve as an iron trap with NGAL-Siderocalin. Iron lipocalin 2 Homo sapiens