Title : Effect of trastuzumab interchain disulfide bond cleavage on Fcγ receptor binding and antibody-dependent tumour cell phagocytosis.

Pub. Date : 2016 Jan

PMID : 26254483






1 Functional Relationships(s)
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1 In this study, the disulfide bonds within the IgG1 trastuzumab (TRA), which is specific for HER2, were cleaved by mild S-sulfonation or by mild reduction followed by S-alkylation with three different reagents. Disulfides erb-b2 receptor tyrosine kinase 2 Homo sapiens