Title : Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.

Pub. Date : 2015 Nov

PMID : 26253087

1 Functional Relationships(s)
Compound Name
Protein Name
1 We show that in MAECs (mouse aortic endothelial cells), the PPARbeta/delta (peroxisome- proliferator-activated receptor beta/delta) agonist GW0742 prevented the decreased A23187-stimulated NO production, phosphorylation of eNOS (endothelial nitric oxide synthase) at Ser1177 and increased intracellular ROS levels caused by exposure to palmitate in vitro. Palmitates peroxisome proliferator activator receptor delta Mus musculus