Title : Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells.

Pub. Date : 2015 Oct

PMID : 26252736






1 Functional Relationships(s)
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1 In HT29 cells, immunoprecipitated PKM2 revealed decreased O-GlcNAc and serine phosphorylation levels after siOGT knockdown, but increased levels after treatment with Thiamet-G, an inhibitor of O-GlcNAcase (OGA). thiamet G pyruvate kinase M1/2 Homo sapiens