Pub. Date : 2015
PMID : 26252654
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent studies have shown that breast CAFs overexpress the chemokine CXCL1, a key regulator of tumor invasion and chemo-resistance. | cafs | C-X-C motif chemokine ligand 1 | Homo sapiens |
| 2 | Increased expression of CXCL1 in CAFs correlated with poor patient prognosis, and was associated with decreased expression of TGF-beta signaling components. | cafs | C-X-C motif chemokine ligand 1 | Homo sapiens |
| 3 | The goal of these studies was to understand the role of TGF-beta in regulating CXCL1 expression in CAFs, using cell culture and biochemical approaches. | cafs | C-X-C motif chemokine ligand 1 | Homo sapiens |
| 4 | We found that TGF-beta treatment decreased CXCL1 expression in CAFs, through Smad2/3 dependent mechanisms. | cafs | C-X-C motif chemokine ligand 1 | Homo sapiens |
| 5 | HGF/c-Met signaling in CAFs was required for activity of NF-kappaB, a transcriptional activator of CXCL1 expression. | cafs | C-X-C motif chemokine ligand 1 | Homo sapiens |