Pub. Date : 2015
PMID : 26251675
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-101 is a microRNA involved in a negative feedback circuit with EZH2 in different normal and tumor tissues. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 2 | To that, miR-101 can behave as a tumor suppressor in several cancers by repressing EZH2 expression. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 3 | RESULTS: Herein, we report that miR-101 is down-regulated in eRMS patients and in tumor cell lines compared to their controls showing an inverse pattern of expression with EZH2. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 4 | We also show that miR-101 is up-regulated in eRMS cells following both genetic and pharmacological inhibition of EZH2. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 5 | In turn, miR-101 forced expression reduces EZH2 levels as well as restrains the migratory potential of eRMS cells and impairs their clonogenic and anchorage-independent growth capabilities. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 6 | This phenomenon is associated to reduced H3K27me3 levels at the same regulatory locus, indicating that EZH2 directly targets miR-101 for repression in eRMS cells. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 7 | CONCLUSIONS: Altogether, our data show that, in human eRMS, miR-101 is involved in a negative feedback loop with EZH2, whose targeting has been previously shown to halt eRMS tumorigenicity. | mir-101 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |