Title : AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation.

Pub. Date : 2015 Oct

PMID : 26236947






2 Functional Relationships(s)
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1 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens
2 Moreover, AMPK-induced GSK3beta and SIRT1 activities were found to be responsible for inhibiting c-Myc-mediated upregulation of MTDH, as LiCl (an inhibitor of GSK3beta) and EX-527 (an inhibitor of SIRT1) reversed AICAR-mediated downregulation of c-Myc and MTDH expressions. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens