Title : Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways.

Pub. Date : 2015

PMID : 26222683






1 Functional Relationships(s)
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1 Baicalein inhibited the cisplatin-induced expression of iNOS, TNF-alpha, IL-6 and mononuclear cell infiltration and concealed redox-sensitive transcription factor NF-kappaB activation via reduced DNA-binding activity, IkappaBalpha phosphorylation and p65 nuclear translocation in kidneys. Cisplatin tumor necrosis factor Mus musculus