Title : Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress.

Pub. Date : 2015

PMID : 26218895






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Activation of PARP-1 in response to oxidative stress catalyzes the covalent attachment of the poly (ADP-ribose) (PAR) groups on itself and other acceptor proteins, utilizing NAD+ as a substrate. NAD poly (ADP-ribose) polymerase family, member 1 Mus musculus
2 Overactivation of PARP-1 depletes intracellular NAD+ influencing mitochondrial electron transport, cellular ATP generation and, if persistent, can result in necrotic cell death. NAD poly (ADP-ribose) polymerase family, member 1 Mus musculus