Pub. Date : 2015 Oct 1
PMID : 26217035
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21. | Doxorubicin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Because c-Abl promotes expression of the cyclin-dependent kinase inhibitor p21 upon stimulation with the DNA-damaging agent Adriamycin (doxorubicin), we analysed the involvement of JunB in Adriamycin-induced p21 expression. | Doxorubicin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Because c-Abl promotes expression of the cyclin-dependent kinase inhibitor p21 upon stimulation with the DNA-damaging agent Adriamycin (doxorubicin), we analysed the involvement of JunB in Adriamycin-induced p21 expression. | Doxorubicin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Because c-Abl promotes expression of the cyclin-dependent kinase inhibitor p21 upon stimulation with the DNA-damaging agent Adriamycin (doxorubicin), we analysed the involvement of JunB in Adriamycin-induced p21 expression. | Doxorubicin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | Taken together, these results suggest that, although JunB represses p21 promoter activity, c-Abl phosphorylates JunB and conversely inhibits its suppressive role on p21 promoter activity upon Adriamycin stimulation. | Doxorubicin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 6 | Therefore JunB is likely to be a key target of c-Abl in expression of p21 in Adriamycin-induced DDR. | Doxorubicin | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |