Title : Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db mice.

Pub. Date : 2016 Feb

PMID : 26211973






2 Functional Relationships(s)
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1 Chronic treatment of db/db mice with antidiabetic drugs such as metformin, glibenclamide and insulin glargine significantly decreased Abeta influx across the BBB determined by intra-arterial infusion of (125)I-Abeta(1-40), and expression of the receptor for advanced glycation end products (RAGE) participating in Abeta influx. Metformin amyloid beta (A4) precursor protein Mus musculus
2 Chronic treatment of db/db mice with antidiabetic drugs such as metformin, glibenclamide and insulin glargine significantly decreased Abeta influx across the BBB determined by intra-arterial infusion of (125)I-Abeta(1-40), and expression of the receptor for advanced glycation end products (RAGE) participating in Abeta influx. Metformin amyloid beta (A4) precursor protein Mus musculus